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Organic compounds that contain a carboxyl group bonded to an organic functional group; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from carboxylic acids.
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Icerguastat (Sephin1) is a Guanabenz derivative that selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A). It functions by inhibiting eIF2α dephosphorylation, which prolongs the protective cellular response and demonstrates an anti-prion effect.
Selectively inhibits the phosphatase regulatory subunit PPP1R15A (R15A).
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Bragsin1 is a potent, selective, and noncompetitive inhibitor of the ArfGEF BRAG2, which inhibits Arf GTPase activation with an IC50 of 3 μM. It functions as a noncompetitive interfacial inhibitor by binding to the PH domain of BRAG2 and does not affect the Sec7 domain of human ArfGEFs. Bragsin1 also exhibits anti-cancer activity.
Potent, selective, and noncompetitive inhibitor of ArfGEF BRAG2.
Inhibits Arf GTPase activation with an IC50 of 3 μM.
Binds to the PH domain of BRAG2.
No effect on the Sec7 domain of human ArfGEFs.
Exhibits anti-cancer activity.
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(S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. It is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. It can also be used for hypertension, angina pectoris, and myocardial infarction.
Non-cardioselective β-adadrenergic blocker
Used for intraocular pressure (glaucoma)
Prevents production of aqueous humor
Suitable for hypertension
Suitable for angina pectoris
Suitable for myocardial infarction
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Amino-PEG3-CH2COOH is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits the ubiquitin-proteasome system
Selectively degrades target proteins
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